Sulfated tungstate catalyzed selective N-monoalkylation of primary amines with alcohol

Authors: Sagar P. Pathare, Krishnacharya G. Akamanchi

Abstract:
We have developed an environmentally benign protocol for N-monoalkylation of primary amines with alcohols using sulfated tungstate as heterogeneous catalyst. Elimination of formation of overalkylated amines as by-products, use of alcohols as alkylating agent has resulted in high atom-economy transformation. In addition efficient, mild reaction conditions, easy product isolation and reusability of the catalyst are attractive features. The developed protocol has been successfully applied for N-monoalkylation of aromatic as well aliphatic amines with different alcohols.

Keywords:
N-monoalkylation
Sulfated tungstate
Heterogeneous catalysis
Amines
Alcohol

Published in: Applied catalysis A: General  (Volume 452, Pages 1-222, 15 February 2013)

Publisher: Elsevier

ISSN Information: 0926-860X

Sulfated tungstate catalyzed selective N-monoalkylation of primary amines with alcohol

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