Synthesis of fragrance compounds from acyclic monoterpenes: Rhodium catalyzed hydroformylation and tandem hydroformylation/acetalization of linalool and β-citronellene
Authors: Camila G. Vieira, Eduardo N. dos Santos, Elena V. Gusevskaya
Abstract:
Rhodium-catalyzed hydroformylation of acyclic monoterpenic compounds, i.e., linalool and - citronellene, was studied in toluene and ethanol solutions in the presence of PPh3 or P(O-o-t BuPh)3 ligands. Although both substrates have a monosubstituted terminal double bond, they show different behavior under the hydroformylation conditions. In toluene, linalool gave almost quantitatively a cyclic hemiacetal; whereas the hydroformylation of -citronellene resulted in two isomeric aldehydes also in a nearly quantitative combined yield. The reactions occurred approximately two times faster in ethanol than in toluene giving the corresponding acetals even in the absence of additional acid co-catalysts. In the absence of phosphorous ligands, linalool (differently from -citronellene) was very resistant to hydroformylation probably due to the binding with rhodium through both the double bond and the hydroxyl group to form stable chelates. The P(O-o-t BuPh)3 ligand exerted a remarkable effect on the reactivity of both substrates accelerating the reactions by 5–20 times as compared to the system with PPh3. Several fragrance compounds were obtained in high yields through a simple one-pot procedure starting from the substrates easily available from natural bio-renewable resources.
Keywords:
Acetalization
Citronellene
Hydroformylation
Linalool
Monoterpenes
Rhodium
Published in: Applied catalysis A: General (Volume 466, Pages 1-314, 10 September 2013)
Publisher: Elsevier
ISSN Information: 0926-860X
Synthesis of fragrance compounds from acyclic monoterpenes: Rhodium catalyzed hydroformylation and tandem hydroformylation/acetalization of linalool and β-citronellene
- Vòng Sơ Khảo Cuộc Thi Đại Sứ Văn Hóa Đọc Năm 2024
- Ngày hội sách “CITTADELLA” khuyến khích và tôn vinh vai trò của sách trong sinh viên Bách khoa
- Cuộc Thi Ảnh “Khoảnh Khắc VNUHCM Libraries”
- Ngày hội Văn hóa đọc lần VI
- Ngày hội văn hóa đọc lần V
- Ngày hội văn hóa đọc lần II
- Ngày hội văn hóa đọc lần IV
- Ngày hội văn hóa đọc lần III
- Tiếp GS Omer Mert Denizci, Trường ĐH Marmara Thổ Nhĩ Kỳ
- Tiếp Cô Claudia Tarzariol Từ The University Of Trento, Italy (Unitrento)
- Tiến sĩ kiều bào Mỹ tặng sách trị giá 150.000 USD cho sinh viên bách khoa
- Khảo sát ý kiến bạn đọc
-
Trực tuyến:21
-
Hôm nay:3900
-
Tuần này:6663
-
Tuần trước:35602
-
Tháng trước:39502
-
Tất cả:4061398